San Diego is quite large when you add in all the communities... but if you need to be down by the convention center, I would recommend the Gas Lamp Quarter hotels... and specifically the Horton Grand (an old Victorian hotel with Victoriana furnishings), The Keating (very upscale, contemporary but the facade is old - don't let that fool you) and the Westgate. I've seen The Keating and the Westgate offered on LL... maybe there is something for them now which could save you a few $$.
San Diego is great fun and has great restaurants... try to get in a San Diego Padres game if you can, head off to SeaWorld and of course, spend an afternoon in Old Town. Then theres always a trip up to LaJolla or across the boarder into Tijuana (don't forget your passport) and getting to Tijuana is easy with the Tijuana trolley - it takes you right to the border and you walk across. We've done this several times and headed off to the musuems in Tijuana as well as the bull fights!
Hi, I absolutely LOVE the Hotel Del Coronado. We stayed 3 nights on an anniversary trip in December of 2006 in the Victorian Section. This is a full scale resort with many nice amenities and so much history and charm. It is located right on the ocean, it was a nice base for visiting SeaWorld and La Jolla on day trips from the resort. Any further questions on the Del, feel free to ask!
As a child we used to spend many a summer vacation in San Diego either at the LaJolla Beach and Tennis Club (which is really great) or at the Del Coronado. Unfortunately, the Del has gotten very, very touristy - to the point that bus loads, and I mean bus loads, of toursits pull up and spend time wandering around. It makes it kind of tough if you are staying there ie: trying to get into the restaurants, having to wear special bracelets to get you into the pool area etc... I'm not sure that these kinds of crowds would be there at this time of year...but you never know. When it's not crowded, it is really wonderful, but one other note - since San Diego is so large, you might want to check how far away it is from your business needs.
You did not mention whether or now you would have a car, so I will assume you will not. If you are on convention business, then the two closest hotels would be the Hyatt and Marriott. Both have great San Diego Bay views and just a very short walk from Seaport Village. There is also the Gaslamp Hilton, Omni (right next to Petco Park) and the newly opened Hard Rock Hotel - which is right in the Gaslamp and just across the street from the convention center. All very nice hotels within walking distance of numerous restaurants and nightspots.
I hope you have a great trip, I also agree that La Jolla area is really worth spending some time in if you can. We loved the Cove there, it is just a short walk away from Prospect St. also where you will find some nice restaurants and shops, the Crab Catcher is a great place to grab a bite to eat in La Jolla. George's California Modern, also on Prospect St. is fantastic if you could squeeze in a meal there.