Originally Posted by
breakingtrails
First of all, September/October is probably the best time to visit Argentina and Chile. The spring is fairly warm and dry, everything is green and beautiful.
To answer thepiranha, the road between Mendoza and BA is pretty boring and there is honestly nothing worth a stop. I would definitely rather fly and start exploring in Mendoza.
Omegaet: if you are into food and wine, both Santiago and Mendoza are worth a visit. From Santiago you should visit Casablanca and Colchagua valleys and try some Carmenere, their signature grape. Once in Mendoza, there are two main wine regions, Primera Zona and Uco Valley. There are a few hotels inside the wineries there, with Cavas Wine Lodge as the best option.
In September the Glaciers National Park opens its season, so I would fly south from Mendoza to Calafate and spend 3-4 nights in that region.
You can then visit Iguazu Falls that although very touristy, it is also quite unique and can be combined with the Ibera Wetlands which are fantastic for nature lovers and still quite off the beaten path.
You can then fly directly to Salta and explore that region which is very different from everything else in Argentina, with the native communities still very much alive and some of the most spectacular landscapes in the continent.