21c Museum Hotel St. Louis

Saint Louis, Missouri

8.3 Moderate Deluxe

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Choose Your Room

We recommend booking a stay with free cancellation in case your plans change.

S2Q
Guest room, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Guest room

  • Bunk room

USD $ 149 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until December 15, 2025 to cancel this reservation without penalty.

USD $149 /nt
$522 for 3 nights
including taxes & fees
Price breakdown

D1K
Deluxe room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 1 King bed

  • Deluxe King accessible
  • Accessible room

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage credit, once per stay
  • • Upgrade (based on availability)

You have until December 15, 2025 to cancel this reservation without penalty.

USD $177 /nt
$618 for 3 nights
including taxes & fees
Price breakdown

BEST FLEXIBLE RATE

You have until December 15, 2025 to cancel this reservation without penalty.

USD $157 /nt
$550 for 3 nights
including taxes & fees
Price breakdown

D2Q
Luxury room, 1 Double or Full bed, 1 Queen bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Luxury room, 1 Double or Full bed, 1 Queen bed

  • Luxury Double Queen

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage credit, once per stay
  • • Upgrade (based on availability)

You have until December 15, 2025 to cancel this reservation without penalty.

USD $240 /nt
$839 for 3 nights
including taxes & fees
Price breakdown

BEST FLEXIBLE RATE

You have until December 15, 2025 to cancel this reservation without penalty.

USD $213 /nt
$746 for 3 nights
including taxes & fees
Price breakdown

E2Q
Deluxe room, 2 Double or Full beds, 1 Queen bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 2 Double or Full beds, 1 Queen bed

  • Deluxe Double Queen roll in shower
  • Accessible room

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage credit, once per stay
  • • Upgrade (based on availability)

You have until December 15, 2025 to cancel this reservation without penalty.

USD $240 /nt
$839 for 3 nights
including taxes & fees
Price breakdown

BEST FLEXIBLE RATE

You have until December 15, 2025 to cancel this reservation without penalty.

USD $213 /nt
$746 for 3 nights
including taxes & fees
Price breakdown

P2Q
Loft, 1 Double or Full bed, 1 Queen bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Loft, 1 Double or Full bed, 1 Queen bed

  • Loft Double Queen
  • Loft

USD $ 221 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until December 15, 2025 to cancel this reservation without penalty.

USD $221 /nt
$774 for 3 nights
including taxes & fees
Price breakdown

T1K
Luxury room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Luxury room, 1 King bed

  • Luxury King suite

USD $ 359 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until December 15, 2025 to cancel this reservation without penalty.

USD $359 /nt
$1,260 for 3 nights
including taxes & fees
Price breakdown

P1K
Suite, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Suite, 1 King bed

  • Library King suite

USD $ 679 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until December 15, 2025 to cancel this reservation without penalty.

USD $679 /nt
$2,382 for 3 nights
including taxes & fees
Price breakdown

Please note, room photos and descriptions are representative of the room category. Actual rooms may vary from what is shown. Upgrades, early check-in, and late check-out are based on availability.

About the Hotel

21c Museum Hotels reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. Located in the heart of downtown St. Louis, and a short walk from the City Museum and CITYPARK stadium, 21c Museum Hotel St. Louis includes a 173-room boutique hotel, contemporary art museum, Idol Wolf restaurant, Good Press café, and Locust Street Athletic and Swim Club, a full-service wellness center. With more than 14,000 square feet of exhibition and meeting & event space seamlessly integrated into all areas of the property, there are opportunities to discover contemporary art around every corner.

Location

21c Museum Hotel St. Louis
1528 Locust Street
Saint Louis, Missouri 63103

Nearest Airport: STL

Features and Amenities

  • General Information
  • Pet Friendly
  • Dining
  • Cafe
  • Bar & Lounge
  • On-Site Amenities
  • Pool
  • Spa Services
  • Laundry Service
  • Fitness Center
  • WiFi
  • 24-Hour Front Desk
  • In-Room Amenities
  • Air Conditioning
  • Hair Dryers
  • Flat-Screen Televisions
  • Coffee & Tea Facilities
  • Blackout Curtains
  • Business
  • Business Center/Services
  • Nearby
  • Museums
  • Interests
  • Hotels
  • Signature Perks

Reviews for 21c Museum Hotel St. Louis

Rude Front Desk

TripAdvisor Traveler Review Rating Reviewed 3 days ago

So get this, I call the front desk so I could place an in-room dining order. The person on the other end asks in a very exasperated tone, "Did you try placing the order through the TV?" He was soooo annoyed he had to take my order over the phone. Bro, you aren't that busy. After taking the order, he litterally just hangs up. No confirmation, no estimated time, nothing. I hope I get more order. I guess we'll see. Hahaha. 🤡🤡🤡

Robbie B


Booking cancelled by whom?

TripAdvisor Traveler Review Rating Reviewed 2 weeks ago

My son and I had booked a double queen room for one night several weeks before our stay through booking.com.a couple of days before we arrived we were in formed that our booking had been cancelled. Booking.com denied they had cancelled it. The hotel denied they had cancelled it. When we got to the hotel all they could offer us was a bunk room, which reluctantly we had to accept. Our thoughts were that the hotel cancelled the booking because they could re-book it at a higher rate. Hotel OK, but their booking handling must be questioned.

Q2582TRarthurh - Wakefield, United Kingdom


Must-see

TripAdvisor Traveler Review Rating Reviewed 2 weeks ago

Hotel is absolutely gorgeous, the restaurants had delicious food, and all the staff we interacted with were very hospitable. It is such a cool concept to have a museum inside a hotel and we really enjoyed the art.

Autumn D


Nice hotel in downtown STL…finally

TripAdvisor Traveler Review Rating Reviewed 1 month ago

There are few new hotels downtown and this is a breath of fresh air. I highly recommend; rooms are nice, food is good, cocktail bar is good, breakfast and coffee bar are good and athletic center is wonderful. Steam room and sauna and lap pool with a jacuzzi. I enjoyed the lavazza coffee in the room, as well.

Chris I


STL 21c Musuem Hotel Experience

TripAdvisor Traveler Review Rating Reviewed 2 months ago

Loved the hotel, the art and the museum experience. Shout out to the orange penguin! The staff was very friendly and welcoming.

Haritha N


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