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We recommend booking a stay with free cancellation in case your plans change.
Guest room
You have until December 15, 2025 to cancel this reservation without penalty.
USD $ 157 /nt
You have until December 15, 2025 to cancel this reservation without penalty.
You have until December 15, 2025 to cancel this reservation without penalty.
Luxury room, 1 Double or Full bed, 1 Queen bed
USD $ 213 /nt
You have until December 15, 2025 to cancel this reservation without penalty.
You have until December 15, 2025 to cancel this reservation without penalty.
Deluxe room, 2 Double or Full beds, 1 Queen bed
USD $ 213 /nt
You have until December 15, 2025 to cancel this reservation without penalty.
You have until December 15, 2025 to cancel this reservation without penalty.
You have until December 15, 2025 to cancel this reservation without penalty.
Luxury room, 1 King bed
You have until December 15, 2025 to cancel this reservation without penalty.
Suite, 1 King bed
You have until December 15, 2025 to cancel this reservation without penalty.
Please note, room photos and descriptions are representative of the room category. Actual rooms may vary from what is shown. Upgrades, early check-in, and late check-out are based on availability.
21c Museum Hotels reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. Located in the heart of downtown St. Louis, and a short walk from the City Museum and CITYPARK stadium, 21c Museum Hotel St. Louis includes a 173-room boutique hotel, contemporary art museum, Idol Wolf restaurant, Good Press café, and Locust Street Athletic and Swim Club, a full-service wellness center. With more than 14,000 square feet of exhibition and meeting & event space seamlessly integrated into all areas of the property, there are opportunities to discover contemporary art around every corner.
21c Museum Hotel St. Louis
1528 Locust Street
Saint Louis, Missouri
63103
Nearest Airport: STL
So get this, I call the front desk so I could place an in-room dining order. The person on the other end asks in a very exasperated tone, "Did you try placing the order through the TV?" He was soooo annoyed he had to take my order over the phone. Bro, you aren't that busy. After taking the order, he litterally just hangs up. No confirmation, no estimated time, nothing. I hope I get more order. I guess we'll see. Hahaha. 🤡🤡🤡
Robbie B
My son and I had booked a double queen room for one night several weeks before our stay through booking.com.a couple of days before we arrived we were in formed that our booking had been cancelled. Booking.com denied they had cancelled it. The hotel denied they had cancelled it. When we got to the hotel all they could offer us was a bunk room, which reluctantly we had to accept. Our thoughts were that the hotel cancelled the booking because they could re-book it at a higher rate. Hotel OK, but their booking handling must be questioned.
Q2582TRarthurh - Wakefield, United Kingdom
Hotel is absolutely gorgeous, the restaurants had delicious food, and all the staff we interacted with were very hospitable. It is such a cool concept to have a museum inside a hotel and we really enjoyed the art.
Autumn D
There are few new hotels downtown and this is a breath of fresh air. I highly recommend; rooms are nice, food is good, cocktail bar is good, breakfast and coffee bar are good and athletic center is wonderful. Steam room and sauna and lap pool with a jacuzzi. I enjoyed the lavazza coffee in the room, as well.
Chris I
Loved the hotel, the art and the museum experience. Shout out to the orange penguin! The staff was very friendly and welcoming.
Haritha N
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